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March 2010 Vol. 138 , No. 3

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Clinical—Alimentary Tract

Low Risk of Colorectal Cancer and Advanced Adenomas More Than 10 Years After Negative Colonoscopy

Hermann Brenner, Ulrike Haug, Volker Arndt, Christa Stegmaier, Lutz Altenhofen, Michael Hoffmeister

Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies. In a study of participants in the German colonoscopy screening program, we determined the prevalence of colorectal neoplasias detected at screening colonoscopy among subjects who had undergone a previous colonoscopy without detection of polyps (negative colonoscopy). Data were compared with that from subjects who had not received colonoscopies.

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Gastroenterology, the official journal of the AGA Institute, is the number one journal in the field of gastrointestinal disease and ranks in the top one percent of all biomedical journals. More...

Issue Highlights

Clinical—Alimentary Tract

Proton-Pump Inhibitor Use Is Not Associated With Osteoporosis or Accelerated Bone Mineral Density Loss

Laura E. Targownik, Lisa M. Lix, Stella Leung, William D. Leslie

Efficacy of Linaclotide for Patients With Chronic Constipation

Anthony J. Lembo, Caroline B. Kurtz, James E. MacDougall, B.J. Lavins, Mark G. Currie, Donald A. Fitch, Brenda I. Jeglinski, Jeffrey M. Johnston

Clinical Advances in Liver, Pancreas, and Biliary Tract

Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

Henk W. Reesink, Gregory C. Fanning, Khalid Abou Farha, Christine Weegink, André Van Vliet, Gerben van 't Klooster, Oliver Lenz, Fatima Aharchi, Kris Mariën, Pieter Van Remoortere, Herman de Kock, Fabrice Broeckaert, Paul Meyvisch, Els Van Beirendonck, Kenneth Simmen, René Verloes

Imaging and Advanced Technology

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

Hamed Laroui, Guillaume Dalmasso, Hang Thi Thu Nguyen, Yutao Yan, Shanthi V. Sitaraman, Didier Merlin

Basic—Alimentary Tract

Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer

J. Joshua Smith, Natasha G. Deane, Fei Wu, Nipun B. Merchant, Bing Zhang, Aixiang Jiang, Pengcheng Lu, J. Chad Johnson, Carl Schmidt, Christina E. Bailey, Steven Eschrich, Christian Kis, Shawn Levy, M. Kay Washington, Martin J. Heslin, Robert J. Coffey, Timothy J. Yeatman, Yu Shyr, R. Daniel Beauchamp

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

Melanie H. Kucherlapati, Kyeryoung Lee, Andrew A. Nguyen, Alan B. Clark, Harry Hou, Andrew Rosulek, Hua Li, Kan Yang, Kunhua Fan, Martin Lipkin, Roderick T. Bronson, Linda Jelicks, Thomas A. Kunkel, Raju Kucherlapati, Winfried Edelmann

Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro

Andres I. Roig, Ugur Eskiocak, Suzie K. Hight, Sang Bum Kim, Oliver Delgado, Rhonda F. Souza, Stuart J. Spechler, Woodring E. Wright, Jerry W. Shay

Basic—Liver, Pancreas, and Biliary Tract

Induction of p53 Renders ATM-Deficient Mice Refractory to Hepatocarcinogenesis

Narci Teoh, Pawan Pyakurel, Yock Young Dan, Karen Swisshelm, Jing Hou, Claudia Mitchell, Nelson Fausto, Yansong Gu, Geoffrey Farrell
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Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial

Jean–Frédéric Colombel, William J. Sandborn, Paul Rutgeerts, Robert Enns, Stephen B. Hanauer, Remo Panaccione, Stefan Schreiber, Dan Byczkowski, Ju Li, Jeffrey D. Kent, Paul F. Pollack

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

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MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

Fanyin Meng, Roger Henson, Hania Wehbe–Janek, Kalpana Ghoshal, Samson T. Jacob, Tushar Patel


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News and Announcements

Gastroenterology in the News

Gastroenterology has been featured in The New York Times, The New York Times Well Blog, the Guardian, Reuters, and on NPR!

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Gastroenterology Welcomes Two New Editors

The AGA's flagship journal, Gastroenterology, has added two new members to its esteemed board of editors: Pankaj Jay Pasricha, MD, and Ralf Kiesslich, MD, PhD. Read more.

AGA Journal Club

AGA members can now rate and comment on select articles from Gastroenterology and CGH by joining the AGA Journal Club. Read compelling commentary provided by club leaders Drs. Geoffrey L. Braden and Ingram M. Roberts. Join now to participate in lively discussions about the ground-breaking research advancing the field of GI.

Thank You to Our 2009 Reviewers

The AGA Institute journals thank their 2009 reviewers for their invaluable input and expertise. To view a full listing of individuals who reviewed for the journal in 2009 click here.

Wanted: Editor-in-Chief for Gastroenterology

Applications due April 1, 2010. Term begins July 1, 2011. Read more.

More news and announcements

Review

History, Molecular Mechanisms, and Endoscopic Treatment of Barrett's Esophagus

Stuart Jon Spechler, Rebecca C. Fitzgerald, Ganapathy A. Prasad, Kenneth K. Wang

This report is an adjunct to the American Gastroenterological Association Institute’s medical position statement and technical review on the management of Barrett’s esophagus, which will be published in the near future. Those documents will consider a number of broad questions on the diagnosis, clinical features, and management of patients with Barrett’s esophagus, and the reader is referred to the technical review for an in-depth discussion of those topics.


Mini-Reviews and Perspectives

Current and Future Trends in Liver Transplantation in Europe

Philipp Dutkowski, Olivier De Rougemont, Beat Müllhaupt, Pierre—Alain Clavien

The first human orthotopic liver transplantation (OLT) in Europe was performed by Sir Roy Calne of the University of Cambridge, United Kingdom, in 1968, only 1 year after the first successful human OLT reported by Thomas Starzl in the United States.


Imaging and Advanced Technology

Comparison of Probe-Based Confocal Laser Endomicroscopy With Virtual Chromoendoscopy for Classification of Colon Polyps

Anna M. Buchner, Muhammad W. Shahid, Michael G. Heckman, Murli Krishna, Marwan Ghabril, Muhammad Hasan, Julia E. Crook, Victoria Gomez, Massimo Raimondo, Timothy Woodward, Herbert C. Wolfsen, Michael B. Wallace

Probe-based confocal laser endomicroscopy (pCLE) allows in vivo imaging of tissue at micron resolution. Virtual chromoendoscopy systems, such as Fujinon intelligent color enhancement and narrow band imaging, also have potential to differentiate neoplastic colorectal lesions.